231 Front Street, Lahaina, HI 96761 [email protected] 808.123.4567

Day: October 13, 2020

England and Tottenham on collision course over Harry Kane’s fitness

José Mourinho is strongly against Gareth Southgate’s plan to start Harry Kane for England in the Nations League tie with Denmark on Wednesday night and has communicated his concerns to the national setup.

The Tottenham manager had urged his England counterpart to handle Kane with care during the international window, given his high workload in the season so far, and the situation became more delicate when the striker felt an issue with his thigh last week.

Related: England’s class of 2018 return favour as Southgate looks back to go forward | David Hytner

Southgate has said Kane is not injured, rather he began to suffer from “muscle fatigue” last Wednesday when he started to train with England, having been given the Monday and Tuesday off. The Football Association sent him for a scan and there has been regular dialogue between their medics and those at Spurs.

Video: CLARET & BLUE: Dean Smith is one of football’s good guys and he proves good guys can win (Birmingham Mail)

CLARET & BLUE: Dean Smith is one of football’s good guys and he proves good guys can win

UP NEXT

UP NEXT

Kane was never going to feature last Thursday in the against Wales, which England won 3-0 and, because he was unable to train fully, he was used only as a 66th-minute substitute in the 2-1 Nations League victory against Belgium on Sunday.

But now club and country are on a collision course, with Southgate wanting to start Kane against Denmark. Spurs argue that the fact Kane was sent for a scan shows the FA is worried that the player is carrying something, and they also know he will always turn out when asked to do so. The club blame the FA in part for the number of games Kane has already played this season. Before Belgium he had played 10 in 29 days – eight of them as a starter.

“Medically, there’s been conversations [with Spurs],” Southgate said. “He started to train on the Wednesday, was a little unhappy with how he felt, so then worked with our medical team the next couple of days. We scanned just to be certain but it’s a muscular fatigue issue rather than an injury so it just needed a bit more confidence.

“He knew by then he could push on a little bit but he just needed a bit more confidence in it and so his training week really wasn’t suitable to start [against Belgium]. I think he’ll have gained more confidence from the spell he had [as a substitute] and so, all being well, we hope he’ll be good to start on Wednesday.”

Source Article

As Dr. Javaid Perwaiz faces trial, the women he treated question decades of care

CHESAPEAKE, Va. — The last time Brittni DuPuy-German saw her trusted gynecologist, she once again explained that the stabbing, mystery pain in her abdomen had not gone away.

It first appeared two years earlier, after she said her doctor, Javaid Perwaiz, surgically tied her tubes. To fix it, he had proposed more surgery — three additional procedures in nine months that she said included a hysterectomy when she was 29. But the pain persisted.

So on Nov. 8, 2019, at his private-practice office, Perwaiz and DuPuy-German discussed the possibility of yet another surgery, she said. He scheduled an ultrasound for just days later, a sign of the efficiency that DuPuy-German had come to expect from her family’s longtime gynecologist. He was her mother’s doctor, her sister-in-law’s doctor, her best friend’s doctor. Perwaiz had delivered DuPuy-German and delivered her children.

Which is why, when her phone buzzed the day after her appointment, she was shocked by the headline she was reading: “Chesapeake doctor tied women’s tubes, performed hysterectomies without their consent, feds say.”

She absorbed the details of the FBI investigation. Her doctor, the news report said, was accused of lying to patients and persuading them to have life-altering surgeries they didn’t need. DuPuy-German began doubting everything Perwaiz had told her about her own body.

“That’s when all of the things that I didn’t question before started popping up,” she said.

As Perwaiz faces trial this week, a year after his arrest, DuPuy-German has received few answers to those questions — even as the FBI’s investigation expanded and the list of alleged victims grew. There are 29 patients specified in court documents and hundreds of others who contacted authorities after the doctor’s arrest.

DuPuy-German, now 32, is not cited in the criminal case but has filed a lawsuit against Perwaiz.

The U.S. attorney’s office for the Eastern District of Virginia would not say how many women in total were allegedly mistreated by Perwaiz, but in a recent trial memorandum prosecutors wrote that “the identified patients are only ‘examples’ of the scheme to defraud.”

The case, which authorities said was launched in 2018 after a hospital employee’s tip, first hinged on one charge each of health-care fraud and false statements. Federal prosecutors now allege that Perwaiz executed an “extensive scheme” spanning nearly a decade that endangered women’s pregnancies, robbed their ability to conceive and pressured them into unnecessary procedures based on unfounded cancer diagnoses and exams using broken equipment.

The more procedures Perwaiz performed, authorities said, the more money he made off insurance companies. He used the profits, according to prosecutors’ trial memorandum, “to support his lavish lifestyle.”

Perwaiz, who is jailed without bond, pleaded not guilty. He has not spoken publicly about the allegations but defense attorneys said in a court document he is “prepared to defend himself at trial.” His lawyers in the criminal case have not responded to multiple requests for comment, but have argued unsuccessfully in numerous motions to dismiss that, among other things, some charges were duplicative.

Six iCoreConnect Products Selected for the Missouri Dental Association Perks Dentist Business Ally Program

Windermere, FL – ( NewMediaWire ) – October 07, 2020 – iCoreConnect, Inc. (OTCQB: ICCT) announces the Missouri Dental Association’s (MDA) acceptance of six iCoreConnect SaaS products into the association’s Perks Dentist Business Ally Program: iCoreRx, iCoreExchange, iCoreDental, iCoreHuddle, iCoreIT, iCoreCodeGenius.

The MDA is a non-profit, professional organization with more than 2,000 members statewide, representing all areas of dentistry. “These six, interconnected products set up dental practices to increase operational speed, gather in-depth analytics for business growth and incorporate managed IT services specific to the dental industry,” explains iCoreConnect President and CEO Robert McDermott.

Members and consumers call on the Missouri Dental Association because they need help finding a resource for a specific situation. “We initially looked at iCoreRx for its integrated e-Prescribing functionality,” states MDA Treasurer Dr. Jon Copeland, DDS. “Once we understood the depth of services offered by iCoreConnect, we wanted to expand the offerings to make each of these resources accessible to our members.”

The MDA Perks Program Dentist Business Ally partnership includes:

–       iCoreRx: Electronic prescribing software

–       iCoreExchange: HIPAA-compliant email 

–       iCoreDental: Practice management system 

–       iCoreHuddle: Practice revenue optimizer

–       iCoreIT: Managed IT services

–       iCoreCodeGenius: Dental medical cross-coding 

iCoreConnect’s entire platform of enterprise software solutions are cloud-based, designed to solve specific business problems and drive revenue. iCoreConnect builds and improves all of its software based on the feedback of currently-engaged healthcare providers. 

iCoreConnect recognitions include:

– Top 25 IoT Solution Providers 2019 by CIO Applications Magazine

– Top 10 Encryption Solution Providers 2018 by Enterprise Security Magazine

– Top 10 Dental Solutions 2018 by Healthcare Tech Outlook

– Top 50 Products of 2017 by Dental Products Report Magazine

iCoreConnect’s unequivocal commitment responding to the market has resulted in agreements with the following organizations:

–       Colorado Dental Association (iCoreExchange)

–       Florida Dental Association Crown Services (iCoreExchange, iCoreDental)

–       Georgia Dental Association (iCoreExchange)

–       Louisiana Dental Association (iCoreExchange)

–       Maine Medical Association (iCoreExchange, iCoreMD)

–       Michigan Dental Association (iCoreExchange, iCoreRx)

–       Mississippi Dental Association (iCoreRx)

–       Missouri Dental Association (iCoreRx, iCoreExchange, iCoreDental, iCoreHuddle, iCoreIT, iCoreCodeGenius)

–       Montana Dental Association (iCoreRx, iCoreDental, iCoreExchange, iCoreHuddle)

–       New Orleans Dental Association (iCoreDental)

–       New York State Dental Association (iCoreExchange)

–       North Carolina Dental Society (iCoreRx, iCoreExchange)

–       Oklahoma Dental Association (iCoreRx)

–       Oregon Dental Association (iCoreRx)

–       South Carolina Dental Association (iCoreExchange, iCoreRx)

–       StartUp Health (iCoreExchange, iCoreMD, iCoreDental, iCoreCodeGenius, iCoreHuddle, iCoreFlex, iCoreRx, iCoreIT)

–       Texas Dental Association Perks Program (iCoreExchange, iCoreDental, iCoreHuddle, iCoreRx)

–       Virginia Dental Association/VDA Services (iCoreExchange, iCoreRx)

–       Wyoming Medical Society (iCoreExchange, iCoreMD, iCoreCodeGenius)

About iCoreConnect

iCoreConnect is a cloud-based software and technology company focused on increasing profit and operational speed in high-compliance industries. iCoreConnect is most notably known for its innovation in solving healthcare business problems. The company’s philosophy is built on a high level of customer feedback, allowing iCoreConnect to respond to the market’s needs. iCoreConnect touts a platform of more than a dozen SaaS enterprise solutions and more than 40 agreements with state or regional healthcare associations. iCoreConnect is a member

Wales wait on Kieffer Moore fitness but Chris Mepham out of Republic match

Wales forward Kieffer Moore was forced off after just 40 minutes at Wembley
Wales forward Kieffer Moore was forced off after just 40 minutes at Wembley

Wales will give Kieffer Moore time to prove his fitness for Sunday’s Nations League match against the Republic of Ireland – but Chris Mepham is out.

Moore has been included in Wales’ match-day squad for the game in Dublin but Mepham has been omitted.

Cardiff City striker Moore was forced off during Thursday’s 3-0 friendly loss to England with a bruised toe.

Bournemouth defender Mepham picked up a knee injury late on and both players travelled to Dublin to be assessed.

“They’re struggling a little bit. We’ll give them as much time as possible,” Wales manager Ryan Giggs had said on Saturday.

“We won’t take any risks if there are any risks.”

Juventus midfielder Aaron Ramsey has linked up with the Wales squad in Dublin after missing the England game.

Ramsey was part of the club’s Covid-19 bubble following an outbreak.

“Aaron’s trained all week with Juve and he joined up with us yesterday when we landed in Dublin,” Giggs added.

“He’s fit to play and in good shape.”

Wales are light on forward options to replace Moore, with Hal Robson-Kanu already out of the squad after breaking his arm.

Moore would be sorely missed if he is ruled out of the Ireland game.

The physically imposing Cardiff City striker has established himself as an important first-team player under Giggs, scoring three goals in his eight appearances to date and helping Wales qualify for next summer’s European Championship.

After their match against the Republic of Ireland, Wales visit Bulgaria on Wednesday.

Ben Davies proud to skipper Wales despite England loss

Although Robson-Kanu’s withdrawal leaves Moore as the only out-and-out centre-forward in the squad, Giggs does not anticipate he will call up a replacement.

That is because Wales are in their own bubble, an enclosed environment to comply with coronavirus protocols, and any additional call-ups would require testing before they can join the squad for training.

“No, it will be very difficult because we’re in the bubble,” Giggs said when asked if Wales might call for cover.

“We have got other options but hopefully he will be okay and it is only bruised.”

Banner Image Reading Around the BBC - BlueFooter - Blue

Source Article

‘Extreme Pain, but Also Extreme Joy’

Unlike Brown, Almodovar did not have the unmedicated birth she had hoped for. She labored for 17 hours at Perez’s birthing center, but the baby wasn’t progressing. Eventually, she decided to go to the hospital.

Panicked, she and her husband raced to the entrance and accidentally left their hospital bag in the car.

But once she was there, she said, “I felt really safe.”

After getting an epidural, “I felt calm and I felt at peace,” Almodovar said. “I was not worried about Covid at all, I just didn’t even think about it.”

She pushed for eight hours, but the baby, while not in distress, was not descending. The nurses told Almodovar that she could either keep pushing or choose to have a cesarean section. Eventually, Almodovar opted for the surgery and delivered a healthy girl.

Now, three months later, her scar is a little sore, but she’s otherwise feeling well. She said she doesn’t have any regrets about having gone to the hospital, and has found some solace in having retained control over her birth plan.

Another mother, Jes Anderson, had also tried to do an unmedicated birth, but was similarly transferred to the hospital after her labor didn’t progress. Her midwife, Drucker, had hospital admission privileges and continued to assist Anderson, who received an epidural and pushed for six more hours before delivering her first child, a boy.

“I never wanted to go to the hospital, but I’m grateful it was there,” said Anderson, who labored for a total of 31 hours.

Source Article

Stamford dentist slashed neck of woman in love triangle

STAMFORD — A local dentist has been indicted for attempted murder after New York police say she attacked her former fiancé’s new girlfriend with a razor blade.



a car parked on the side of a building: Alika Crew, 42, of New Rochelle, N.Y. has been indicted for the attempted murder of her ex-fiance’s new girlfriend, prosecutors say.


© Getty Images

Alika Crew, 42, of New Rochelle, N.Y. has been indicted for the attempted murder of her ex-fiance’s new girlfriend, prosecutors say.


Westchester County District Attorney Anthony A. Scarpino, Jr. said Alika Crew, 42, of New Rochelle, N.Y., has been indicted by a Grand Jury for the July 28 attack on another woman.

Crew was arraigned Wednesday in Westchester County Court before Judge David Zuckerman on charges of second-degree attempted murder, three counts of first-degree assault, two counts of second-degree assault, first-degree unlawful imprisonment and criminal possession of a weapon.

Crew pleaded not guilty to the charges, according to lohud.com.

New Rochelle Police Capt. Cosmo Costa said Crew was employed as a dentist in Stamford. Crew is listed as an orthodontist on the Stein Dental Group’s website. A person who answered the phone at the Springdale office declined to comment on Thursday.

According to her bio on the dental group’s website, Crew grew up in Maryland before attending Brown University, the University of Pennsylvania School of Dental Medicine and The Case Western School of Dental Medicine, where she received her orthodontic certificate and master’s degree in the science of dentistry.

According to the website, Crew has been employed with the dental group “for many years.”

Prosecutors allege that Crew attacked her former fiancé’s new girlfriend, lunging at her from behind the driver’s seat in the victim’s car.

The victim got out of the car and tried to run away, but Crew caught up to her and sliced the woman’s neck with a razor blade, causing significant and possibly permanent damage, prosecutors said. The victim also sustained a serious cut to her hand when she tried to push Crew away, prosecutors said.

The attack occurred a few blocks from where Crew and her ex-fiancé were still living together as the victim was leaving the house after spending the night, prosecutors said.

Prosecutors said Crew initially left the scene as neighbors came the victim’s aid. Crew then returned and pretended to be a “concerned neighbor,” prosecutors said.

The victim identified Crew as the attacker and she was arrested at the scene, prosecutors said.

Crew, who has been free on $200,000 bond, is scheduled to return to court on Nov. 2.

Continue Reading

Source Article

Sean Hannity Attacks Joe Biden’s Mental Fitness Despite Tucker Carlson Previously Saying Tactic Won’t Work

Sean Hannity has attacked Joe Biden’s mental fitness just two weeks after Tucker Carlson said that this tactic was a “mistake” and would not help Donald Trump beat Joe Biden in the election.

Hannity laid into Biden on his Monday night Fox News broadcast for briefly forgetting Sen. Mitt Romney’s name as well as for a recent incident where Biden mistakingly said he was running for senate, not president.

“Maybe somebody on the staff might want to remind the ever forgetful Joe that he is running for president. He’s not running for senator,” Hannity said. “He keeps forgetting, forgets the day of the week, forgets what office he’s running for. He is running for president, not senator. Somebody remind him!”

He went on to say: “He is obviously not capable of leading. He has been hiding the entire campaign, and the corrupt media mob is covering for him.”

However, Hannity may have not gotten the memo, as two weeks ago, Carlson said “it was a mistake to spend so much time focusing on Joe Biden’s mental decline.”

Sean Hannity
Sean Hannity is pictured at Del Frisco’s Grille on April 2, 2018 in New York City. He has said on his show that he believes some parts of the U.S. should end the lockdown in place due to the coronavirus.
Theo Wargo/Getty Images

Carlson said the Trump administration’s attempts to paint Biden as “senile” or suffering from dementia are the wrong tactic and even conceded that the 77-year-old Democrat came across well at the debate.

“Trump isn’t going to win this race by calling Joe Biden senile,” Carlson said. “Nor, by the way, is Joe Biden going to win this race by calling Donald Trump a racist, as he repeatedly did last night. That slander didn’t work four years ago. It will not work now. Because personal attacks rarely work, they rarely determine election outcomes. That’s obvious if you look at the results, but it’s easy to forget it—and many did.”

“As a political matter, the main thing we learned last night is that it was a mistake to spend so much time focusing on Joe Biden’s mental decline,” Carlson said on September 30. “Yes, it’s real. Yes, Joe Biden is fading, we’ve showed you dozens of examples of it for months now.

“But on stage last night, Biden did not seem senile,” he continued. “If you tuned in expecting him to forget his own name—and honestly, we did expect that—you may have been surprised by how precise some of his answers were. Not all of them, but enough of them. Trump isn’t going to win this race by calling Joe Biden senile.”

Another person who seems to have not gotten the memo either is Donald Trump himself.

This morning, the President took aim at his opponent’s mental stability once again in a tweet lambasting Biden for mistakingly saying he was running for senate.

China Tests Entire City For Virus As Europe Tightens Controls

China rushed Tuesday to test an entire city of nine million people within days after a minor coronavirus outbreak in the sprawling country, a far cry from the struggle in Europe to tackle surging infections with tough new steps including partial lockdowns.

The virus is still spreading rapidly worldwide, with over one million deaths and 37 million infections, and many nations that suppressed their first outbreaks now face a second wave.

Without a vaccine, governments are wary of allowing the virus to spread unchecked.

More than four million samples had been collected as of Tuesday in the Chinese city of Qingdao More than four million samples had been collected as of Tuesday in the Chinese city of Qingdao Photo: AFP / STR

China — where Covid-19 first emerged late last year — launched a drive to test all residents of Qingdao after a handful of cases were detected on Sunday.

More than four million samples had been collected and 1.9 million results returned as of Tuesday afternoon, Qingdao authorities said, adding that no new cases had been found beyond already confirmed infections.

Chinese officials intend to test the entire city — around 9.4 million people — by Thursday.

Britain's Prime Minister Boris Johnson has ordered pubs to close early to help stem the virus spread Britain’s Prime Minister Boris Johnson has ordered pubs to close early to help stem the virus spread Photo: AFP / JUSTIN TALLIS

In scenes contrasting with the fumbled testing efforts elsewhere, health workers in protective clothing swiftly set up tents and residents queued deep into Monday night to provide samples.

In Europe, governments are battling to curb surges with new controls and increased testing, while trying to avoid the devastating nationwide lockdowns of March and April.

Dutch Prime Minister Mark Rutte announced the Netherlands will go into “partial lockdown” from 2000 GMT on Wednesday, with all bars, caf?s and restaurants to close for two weeks at least.

French President Emmanuel Macron is expected to announce tighter restrictions and faster testing in a prime-time TV interview Wednesday night, with some media speculating Paris and other cities could face evening curfews.

Map with number of Covid-19 deaths by country as of October 13 at 1100 GMT Map with number of Covid-19 deaths by country as of October 13 at 1100 GMT Photo: AFP / Simon MALFATTO

Hospitals in Paris will have most of their intensive care beds packed with Covid-19 patients as soon as next week, the system’s chief warned Tuesday.

“It’s inevitable,” Martin Hirsch, the head of the 39 hospitals in Paris and its suburbs, told the Parisien newspaper, estimating beds would reach 70-90% capacity by October 24.

Russia on Tuesday reported its highest-ever number of daily virus deaths, at 244, and a record number of new cases at almost 14,000.

With the pandemic already claiming more than one million lives worldwide, scientists in different nations are rushing to develop vaccines and effective treatments With the pandemic already claiming more than one million lives worldwide, scientists in different nations are rushing to develop vaccines and effective treatments Photo: AFP / Yasin AKGUL

Italy imposed new, tougher rules to control a resurgence, including an end to parties, amateur football matches and snacking at bars at night.

Polish Prime Minister Mateusz Morawiecki on Tuesday became the latest high-profile figure to go into quarantine after coming into contact with a person with Covid-19.

And Portugal’s football federation said star striker Cristiano

Diamond Dental Associates LLC, Has The Best Flemington Dentist For Oral Healthcare And Treatment Needs

Diamond Dental Associates LLC, Has The Best Flemington Dentist For Oral Healthcare And Treatment Needs

Flemington, NJ – Members of the Flemington, NJ community who wish to sport the best smiles and enjoy the advantages of top oral health can rest assured that Diamond Dental Associates LLC has the best dentists in the area to deliver these premium services at the most affordable prices. At Diamond Dental Associates LLC, the dental team focuses on providing premium quality dental care and treatment solutions to patients while delivering the best dental experience in the process.

As the leading dental clinic in the area, Diamond Dental Associates LLC has a team of dentists with over three decades of experience who are on the ground to listen to oral health complaints from patients and address the problem. At Diamond Dental Associates LLC, the team employs the use of the latest dental technologies to establish diagnosis and craft treatment plans that are most suitable for the needs of each patient.

Promising the very best dental experience, the top Flemington Dentist at the clinic said: “Here at Diamond Dental Associates LLC, we pledge to provide the finest personal service using state of the art technology for our patients, who will always be welcomed to a warm and caring environment. At Diamond Dental Associates we change lives one smile at a time. We are committed to making every interaction with our patients a positive one. We respect and acknowledge your concerns about the dental treatment you will receive. We recognize that it is difficult for highly fearful people to visit a dental office for needed treatment and we offer services that help you to feel confident that the treatment we provide is in your best interests and fits in with your preferences, lifestyle, and monetary investment.”

As a dental clinic that is constantly working on new ways to address the dental care and treatment needs of patients, Diamond Dental Associates LLC – Flemington Dentist has expanded the services offered to include general dentistry practice which focuses on improving oral health and protecting the mouth from common debilitating conditions. As part of the general dentistry services offered, patients will get to enjoy routine dental examinations, oral cancer screening, teeth cleaning, dental sealants, and more.

Added to this, the dental team at Diamond Dental Associates LLC also offers a wide range of cosmetic dental solutions aimed at improving the appearance and appeal of the teeth. As part of the cosmetic dental solutions offered, patients are welcomed into the clinic to enjoy teeth whitening services aimed at brightening the teeth and smile; cosmetic bonding used to restore decayed teeth, strengthen a weak tooth, close spaces between the teeth, and alter the shape and/or size of the tooth.

The dentists also offer dental veneers that are used to cover up blemishes, chips, cracks, and tooth discoloration; dental implants for restoration of missing or lost teeth; as well as sports mouthguards and sleep apnea treatment.

Visit Diamond Dental Associates LLC at North, 334 NJ-31 #1, Flemington, NJ 08822, or call 908-838-0004. For more information, send an email

Kuur Therapeutics Announces Publication of Interim Phase 1 Data for CAR-NKT Cell Therapy KUR-501 in Nature Medicine

Kuur Therapeutics, a leader in the development of off-the-shelf CAR-NKT cell immunotherapies for the treatment of solid and hematological malignancies, today announced the publication in Nature Medicine of interim findings from its ongoing phase 1 GINAKIT2 clinical trial collaboration with Baylor College of Medicine and Texas Children’s Hospital, in high risk relapsed refractory (R/R) patients with neuroblastoma, a form of childhood cancer.

The interim results demonstrated that expressing the CAR with interlukin-15 (IL-15), a natural protein that supports NKT survival, enhanced the tumor-fighting capabilities and in vivo persistence of autologous NKT cells. Two of three patients studied showed tumor reduction following CAR-NKT infusion: one classified as stable disease and the other as a partial response. Imaging revealed a dramatic reduction in the size and metabolic activity of bone metastases in the patient with the partial response. CAR-NKT cells demonstrated a favorable safety profile and localized to the site of the neuroblastoma tumors.

Kuur is the first company to test CAR-NKT cell therapy in patients. The company’s revolutionary platform engineers CARs on invariant NKT cells, a subset of T lymphocytes. NKT cells represent the next generation of CAR therapy, because this innovative approach harnesses the innate tumor-homing properties of NKT cells, a specialized type of lymphocyte that eliminates tumor-supportive macrophages, activates anti-tumor NK, dendritic and CD8 T cells, and does not induce graft versus host disease when used in an allogeneic setting.

“These results validate the biology of CAR-NKT cells in that they home to tumor and marrow, expand and have tumor killing properties. They also demonstrate safety and enhanced tumor homing capabilities, offering distinct advantages over other cell types for the treatment of solid and hematological tumors,” said Kurt C. Gunter, MD, CMO of Kuur. “Using our novel engineering platform, we have manufactured CAR-NKT cells with high purity and added IL-15 to the CAR construct, which further increases in vivo persistence and anti-tumor activity. We look forward to continuing our research with the experts in cellular and gene therapy at Baylor as we aim to leverage the CAR-NKT cell approach to create more precise and effective therapies for cancer patients, including allogeneic therapies.”

The results published were derived from the three heavily pre-treated, R/R metastatic neuroblastoma patients in dose level 1 (3×106 CAR-NKTs/m2) of the GINAKIT2 clinical study. These data were originally presented at the 23rd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) in May 2020. The trial is currently enrolling at the fourth and highest dose level.

About KUR-501

KUR-501 is an autologous product in which natural killer T (NKT) cells are engineered with a chimeric antigen receptor (CAR) targeting GD2, which is expressed on almost all neuroblastoma tumors. KUR-501 is also designed to address key limitations of current CAR immune cell therapies by secreting the cytokine IL-15, which has been shown in nonclinical studies to increase the persistence of CAR-NKT cells and improve their efficacy within the immunosuppressive tumor microenvironment. KUR-501 is being tested in the phase 1